He said the ongoing security audit by an American security agency will confirm the country's readiness for the flights to New York.
"We are confident that this final audit will see direct flights. Previously, we had 180 issues flagged out but all have been adequately addressed," Macharia said.
"The impact of the direct flight to the Gross Domestic Product will be substantial as Kenya will be a hub," he said.
The final audit is critical as Kenya Airways plans to start direct flights to John F Kennedy International Airport in New York on October 28.
Macharia said exports such as flowers will reach the foreign markets while they are still fresh.
The CS further said the direct flight will cut travel time to the United States by half.