Annual salvia requires low to medium fertility levels between 100 and 200 ppm N and an optimal substrate pH ranging from 5.8 to 6.2. Annual salvia can develop both low and high substrate pH disorders. If the substrate pH drifts <5.8, iron (Fe) and manganese can accumulate at toxic levels and observed as lower leaf black spotting. Substrate pH values >6.5 inhibit Fe availability and induce interveinal chlorosis and stunted plant growth.